Resident Evil 4: Wii edition was released for the Wii on May 31, 2007 in Japan and on June 19, 2007 in the US. It features new controls involving the Wii Remote and Nunchuk, along with the ability to use the GameCube controller or Classic Controller instead. The Wii Remote is able to aim and shoot anywhere on the screen with a reticle that replaces the laser sight found in the other versions. It can also be flicked to use the knife. The Wii edition also includes the extra content from the PlayStation 2 and PC versions, and a trailer for Resident Evil: The Umbrella Chronicles.
Japanese game magazine Famitsu reviewed the game, with two editors giving the game a perfect 10 score, and the remaining pair giving it a 9, resulting in a score of 38 out of 40. The reviewers noted that the game's improved controls offer something fresh and different. One reviewer said that the game offers the feeling of being closer to the action as well as upping the tension. Multiple reviewers agreed that even those who own the original will find something fun and enjoyable in this version.
British magazine NGamer gave the Wii edition a score of 96%, slightly lower than the 97% given to the GameCube version. They praised the visuals, controls and features and commented on the fact that such an "exceptional package" was on sale for a low price; however, when writing about the Wii controls, they said "if you've played the GC version this won't be as special". Official Nintendo Magazine gave the game 94%, 3% less than the original due to it simply not having the same impact it did back then. IGN gave the game a 9.0 out of 10, stating it is the superior edition, but does not push the Wii like it did with GameCube and PS2. The Wiire gave the version an A-, and an "Editor's Choice" award.
GameSpot gave the Wii edition a score of 9.1 out of 10, praised the new controls, but commented on the lack of exclusive Wii features. The Next Level awarded the game a 5 out of 5, citing the Wii version of Resident Evil 4 as "the pinnacle of its existence".